Newsletter

Innovate the way we see life | Tomocube Inc. | April 2025

As a global leader in holotomography (HT), Tomocube introduces the HT-X1 Series to define what truly sets next-generation holotomography apart.

In this newsletter, discover how the second-generation holotomography gives you an edge over conventional methods—pushing the boundaries of live cell imaging beyond what’s possible with other technologies.

Low-Coherence LED for Enhanced 3D Imaging

Holotomography represents a 3D, label-free optical imaging methodology that leverages the refractive index (RI) as an intrinsic quantitative contrast.

While first-generation HT systems employed laser-based coherent illumination, the second generation utilizes a low-coherence LED light source coupled with advanced reconstruction algorithms.

This design shift significantly enhances imaging performance, providing inherent high-speed optical sectioning, improved sample penetration depth, and a superior signal-to-noise ratio. This makes the new generation exceptionally effective for analyzing challenging samples, including tissue sections and 3D cultures.

Explore the featured review ‘Holotomography’ in Nature Review Methods Primers for an in-depth look at low-coherence holotomography and its technical details.

A Break-Through in Label-Free Imaging: Setting a New Standard

Harnessing the advantages of low-coherence HT, Tomocube’s second-generation systems are designed with more powerful features to deliver enhanced performance, greater versatility, and improved usability, setting a new standard for label-free 3D imaging.

Expanded Sample Compatibility

Enhanced depth scanning with minimal speckle noise enables high-content imaging of challenging biological specimens like 3D organoids and thick multicellular layers.

High-Speed, Wide-Field Imaging

A significantly larger field-of-view combined with faster acquisition enables seamless imaging of multi-well plates and large samples, accelerating high-content experiments.

User-Friendly Workflow

Effortless operation with a minimal learning curve. The stage-top incubator and auto calibration simplify time-lapse imaging and long-term studies, ensuring consistent results.

[Focus on Microscopy 2025] Get Hands-On at our Demo Workshop

DEMO WORKSHOP

  • Date & Session: April 15 (Tue) 09:00 | 11:00 | 14:00 | 16:10April 16 (Wed) 09:10 | 11:20
  • Room 205, NTUH International Convention Centre

EXHIBIT BOOTH #7