Newsletter

Innovate the way we see life | Tomocube, Inc. | November 2026

HT-X1 MAX with a plate hotel, robotic arm and analysis workstation

Today we launch HT-X1 MAX, the most advanced holotomography system we have built. It brings label-free 3D imaging to whole, living organoids.

HT-X1 MAX images organoids up to 500 μm deep, in 3D, at single-cell resolution, with no staining, fixation or clearing. It keeps them in culture for days and quantifies nuclei, cell layer and lumen in every organoid, at every time point.

For drug discovery, this changes what an organoid assay can report. 3D measurement reveals responses that 2D size and outline readouts miss. Repeated imaging of the same organoids delivers the full dynamics of a drug response from a single plate. Because nothing is stained or lysed, those organoids remain available for immunostaining, RNA-seq or other downstream assays.

HT-X1 MAX also adds confocal fluorescence, correlating your specific markers with the label-free 3D data. The system is automation-ready: an open API connects it to laboratory automation, and 96-well plate imaging brings the same readouts to screening experiments.

See it for yourself. Watch the HT-X1 MAX launch video.

Launch webinar · 2026-11-17 (Tue) · Three regional sessions

Session times and registration links are at the end of this newsletter.

What you can do with HT-X1 MAX

Human heart organoid, color-coded by depth
Human heart organoid, color-coded by depth.

See deeper

Whole organoids up to 500 μm, in about 15 seconds.

Human iPSC-derived liver organoid, HT optical section
Human iPSC-derived liver organoid.

See inside

Single cells, lipid droplets and secretory granules, without sectioning or labeling.

Mouse hepatic organoid at 0 h and 39 h of culture
Mouse hepatic organoid, imaged every 15 min for 39 h.

See over time

The same organoids, in culture, followed for days.

Cell layer, lumen and nuclei segmented in 3D
Nuclei, cell layer and lumen segmented in 3D.

See and quantify

Cell count, cell layer and lumen volume for every organoid.

Detected organoids marked as kept or excluded by filtering criteria
Detected organoids, kept or excluded by user-defined criteria.

Automation-ready

Organoids detected and filtered in every well. Open API for laboratory automation.

Samples courtesy of KBIOHealth and KRIBB.

Pre-orders are now open.

Talk to us about your organoid models, readouts and throughput.

LAUNCH WEBINAR

Introducing Tomocube HT-X1 MAX | See deeper into live organoids

Junhyung Park
Head of Imaging Team, Tomocube, and product manager of the HT-X1 MAX development project

The session covers the operating principle, imaging data from live organoids, and applications from drug response to long-term culture, followed by Q&A.

2026-11-17 (Tue) · Three regional sessions

  • Asia-Pacific: 15:00 KST/JST · 14:00 China (UTC+8)
  • Europe: 10:00 CET · 09:00 GMT
  • Americas: 16:00 EST · 13:00 PST

Register for your regional session: