Newsletter

Innovate the way we see life | Tomocube Inc. | August 2025

Top 10 Microscopy Innovation

HT-X1™ Plus Wins Microscopy Today Innovation Award 2025

This prestigious recognition places the HT-X1™ Plus system among the Top 10 most innovative microscopy products worldwide, as selected by the Microscopy Society of America (MSA) and Microscopy Today magazine.

This recognition celebrates how far we’ve pushed the boundaries of live cell imaging. It’s more than just engineering — it’s about how our technology is empowering researchers to see deeper, work faster, and make discoveries.

One recent study captures this perfectly.

Research Spotlight: HT‑X1™ Plus Delivering Impact

A new Cell Biomaterials publication from scientists at Gustave Roussy Institute, in collaboration with Alvéole and other partners, showcases the HT-X1™ Plus with Spinning Disk Confocal in action.

Mechanosensitive interactions of tumoroids with an engineered environment promote cell proliferation and enhance drug response detection

Ouni, Emna et al. Cell Biomaterials, https://doi.org/10.1016/j.celbio.2025.100149

In this study, researchers engineered a PEG-acrylate microcavity array with tunable stiffness and viscoelasticity, enabling high-throughput tumoroid culture with real-time biomechanical readouts. This platform allowed them to investigate how mechanical cues in the tumor microenvironment influence tumoroid growth, metabolism, and drug sensitivity.

To capture these complex dynamics, the team utilized the HT-X1™ Plus with Spinning Disk Confocal, which enabled them to:

  • Acquire true 3D images of intact tumoroids without slicing, preserving their native structures.
  • Use label-free holotomography to accurately evaluate drug responses in real-time, avoiding staining artifacts and minimizing phototoxicity and photobleaching.
  • Combine label-free imaging with high-quality 3D fluorescence for correlative, multiscale analysis — from single-cell divisions to collective behaviors within tumoroid arrays.

This powerful integration, paired with the team’s scalable and adaptable tumoroid culture platform, supports standardized and personalized studies across diverse cancer models.
 


See it in action: Watch Emna Ouni’s video from the study to explore for an inside look at how the team conducted their research and applied 3D label-free and fluorescence imaging in practice.

Multimodal imaging of mouse kidney tissue acquired with the HT-X1 Plus with Spinning Disk Confocal. The same field of view is shown in two complementary modalities: on the left, a fluorescence image highlights cell membranes (green, Alexa Fluor 488 wheat germ agglutinin) and actin filaments (red, Alexa Fluor 568 phalloidin) — providing molecular specificity; on the right, a label-free holotomography slice reveals intrinsic cellular structures without additional staining, offering high-contrast 3D morphological information even in thick tissue samples. Together, these modalities combine targeted molecular detail with a comprehensive structural overview.

10‑Year Anniversary: Tomocube TechDay

Join us to celebrate innovation and growth.

On September 15, we’re hosting the Tomocube TechDay — a milestone event led by our CEO, Prof. Yongkeun (Paul) Park. As we mark ten years of growth and breakthroughs, we’re setting the stage for the next chapter.

From our evolving vision to the unveiling of the upcoming product, TechDay will offer fresh perspectives on where Tomocube is headed.

Whether you’re a researcher, investor, engineer, or our future partner, TechDay is your invitation to be part of what’s next.

Mark your calendar! Be part of the reveal.

  • Monday, September 15, 2025
  • Online event