Phase separation

Observe phase separation in live cells and quantify protein condensates


HT offers visualization of liquid-liquid phase separation without markers 


Protein condensate mass can be measured based on the refractive index (RI)

3D visualization

Liquid droplet formation in live cells can be viewed in 3D

Simultaneous HT and fluorescence imaging

HT-2H offers HT and fluorescence imaging to offer you unrestricted design for your experiments

Publications using HT

Published in Nature cell biology cover page (March 2021)

TGF-β-induced DACT1 biomolecular condensates repress Wnt signalling to promote bone metastasis Nat Cell Biol 23, 257–267 (2021).
Tomocube_Label-free 3D Live Cell Imaging_Holotomography_Nature Cell Biology cover

Holotomographic images and quantitative analysis of the aggresomes

Aggresomal sequestration and STUB1-mediated ubiquitylation during mammalian proteaphagy of inhibited proteasomes PNAS 117 (32) 19190-19200 (2020)
Tomocube_Label-free 3D Live Cell Imaging_Holotomography_phase separation


Application note

Coming soon

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